This book reports on cutting-edge research and best practices in the broad fiel of biomedical engineering. Based on the  XLVI Mexican Congress on Biomedical Engineering, CNIB 2023, held on November 2-4, 2023 in Villahermosa Tabasco, Mexico, this first volume of the proceedings covers research topics in biomedical signals and image processing, artificial intelligence, biosensors, and wearable systems, with  applications ranging from disease classification and diagnosis, to health monitoring and medical therapy. All in all, this book provides a timely snapshot on state-of-the-art achievements in biomedical engineering and current challenges in the field. It addresses both researchers and professionals, and it is expect to foster future collaborations between the two groups, as well as international collaborations.