Bringing together an exciting group of knowledge workers, scholars and activists from across fields, this book revisits a foundational question of the Enlightenment: what is "the last or furthest end of knowledge"? It is a book about why we do what we do, and how we might know when we are done. In the reorganization of knowledge that characterized the Enlightenment, disciplines were conceived as having particular "ends," both in terms of purposes and end-points. As we experience an ongoing shift to the knowledge economy of the Information Age, this collection asks whether we still conceptualize knowledge in this way. Does an individual discipline have both an inherent purpose and a natural endpoint? What do an experiment on a fruit fly, a reading of a poem, and the writing of a line of code have in common? Focusing on areas as diverse as AI; biology; Black studies; literary studies; physics; political activism; and the concept of disciplinarity itself, contributors uncover a life after disciplinarity for subjects that face immediate threats to the structure if not the substance of their contributions. These essays - whether reflective, historical, eulogistic, or polemical - chart a vital and necessary course towards the reorganization of knowledge production as a whole. This book is organized around a central pun like all great works of scholarship. It queries the ends of knowledge, but here the "end" might mean telos, completion or cessation. The editors have assembled a genuinely productive and heterogeneous collection, but they wisely acknowledge that their volume is open-ended, unfinished and generative in the spirit of the Enlightenment encyclopedia project which provides its inspiration and warrant.